Ghana Health News API

{
    "totalArticles": 740,
    "articles": [
        {
            "id": "e31a6463aaee9a949398edac1e6c8f68",
            "title": "Immunoreactivity and distribution of Fos in the mouse brain following diverse general anesthetics",
            "description": "General anesthesia induces a range of effects, including unconsciousness, analgesia, amnesia, and immobility. Despite its widespread use for over a century, the underlying mechanisms remain incompletely understood. This study aims to investigate whether different intravenous anesthetics share common neuronal targets. Propofol (180 mg/kg), midazolam (75 mg/kg), and esketamine (250 mg/kg) were intraperitoneally injected in C57BL/6J mice, respectively. After one hour of anesthesia, mice were transcardially perfused, and their brains were examined for Fos protein localization to assess changes in neuronal activity across the central nervous system. The 14 selected regions of interest (ROIs) associated with sleep-wake regulation, emotional stress processing, or pain modulation include: oval division of the bed nucleus of the stria terminalis (ovBNST), basal forebrain (BF), ventrolateral preoptic nucleus (VLPO), paraventricular hypothalamic nucleus (PvH), supraoptic nucleus (SON), central amygdaloid nucleus (CeA), paraventricular thalamic nucleus (PVT), lateral habenular nucleus (LHb), tuberomammillary nucleus (TMN), Edinger-Westphal nucleus (EW), dorsal raphe nucleus (DR), ventrolateral periaqueductal gray (vlPAG), locus coeruleus (LC) and parabrachial nucleus (PB). Following the administration of three different anesthetics, the immunoreactivity of Fos in the 14 ROIs increased in the following brain regions: ovBNST, LHb, PvH, SON, CeA, and EW; however, the BF, PVT, DR, LC, and PB showed no appreciable changes, while the VLPO, TMN, and vlPAG exhibited variable Fos immunoreactivity across the three anesthetic groups. These findings suggest that propofol, midazolam, and esketamine may commonly enhance neuronal activity in specific brain regions, providing new morphological insights into the mechanisms of general anesthesia.",
            "content": "Brown, E. N., Lydic, R. & Schiff, N. D. General anesthesia, sleep, and coma. N Engl. J. Med. 363, 2638–2650 (2010).\nZhang, D., Liu, J., Zhu, T. & Zhou, C. Identifying c-fos expression as a strategy to investigate the actions of general anesthetics on... [10106 chars]",
            "url": "https://www.nature.com/articles/s41598-025-29425-0?error=cookies_not_supported&code=982a246e-5edb-4691-b49f-554f3fa8ed6c",
            "image": "https://www.nature.com/static/images/favicons/nature/favicon-48x48-b52890008c.png",
            "publishedAt": "2025-12-05T12:21:39Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "5f588d161f07ca0cd0a4e307abdca474",
            "title": "New blood tests for multiple cancers gain political backing",
            "description": "As new technology capable of detecting dozens of early-stage cancer types with a single blood test hits the market, support for its use is building.",
            "content": "Dec. 2 (UPI) -- As a new blood tests capable of detecting dozens of cancers in their early stages are hitting the market, disease prevention advocates say political and economic momentum is building for what they call a game-changing breakthrough in ... [8744 chars]",
            "url": "https://www.upi.com/Health_News/2025/12/05/blood-tests-multiple-cancer-types-gain-market-political-momentum/1751764708384/",
            "image": "https://cdnph.upi.com/sv/ph/og/upi/1751764708384/2025/1/0047dd27dc8e999789b1d74e2126e5e4/v1.5/New-blood-tests-for-multiple-cancers-gain-political-backing.jpg",
            "publishedAt": "2025-12-05T11:53:41Z",
            "lang": "en",
            "source": {
                "id": "887e9e707c79cca3398c8d4e0e1c2d60",
                "name": "upi.com",
                "url": "https://www.upi.com"
            }
        },
        {
            "id": "8216ec4340888d5ddcbe1e185315b2c6",
            "title": "Restless legs syndrome linked to higher Parkinson’s disease risk",
            "description": "The study shows restless legs syndrome is associated with higher Parkinson's disease incidence, raising questions about treatment impacts on symptoms.",
            "content": "A 15-year national health analysis reveals that people with restless legs syndrome are more likely to develop Parkinson’s. Treatment choices may play a surprising role in how soon symptoms appear.\nStudy: Risk of Parkinson Disease Among Patients With ... [4750 chars]",
            "url": "https://www.news-medical.net/news/20251205/Restless-legs-syndrome-linked-to-higher-Parkinsone28099s-disease-risk.aspx",
            "image": "https://www.news-medical.net/images/news/ImageForNews_825624_17649299725717087.jpg",
            "publishedAt": "2025-12-05T10:22:00Z",
            "lang": "en",
            "source": {
                "id": "f2ca7a45d20357cb42858868cb4a4946",
                "name": "News-Medical",
                "url": "https://www.news-medical.net"
            }
        }
    ]
}