Singapore Science News API

{
    "totalArticles": 14892,
    "articles": [
        {
            "id": "34446aadbc0bb6603e509b3f43c34719",
            "title": "Field component modulation of vortex beams in uniaxial crystals driven by angular and topological charge dependencies",
            "description": "We investigate the propagation of linearly polarized vortex–Gaussian beams carrying topological charge M through a rutile uniaxial crystal at arbitrary angles relative to the optical axis. Using a full vectorial numerical model, we provide a systematic mapping of how both the propagation angle $$\\theta$$ and the topological charge jointly govern the evolution of the transverse and longitudinal electric–field components. The results reveal a pronounced and angle-dependent modulation of all field components, accompanied by a strong and predictable amplification with increasing M. In particular, the longitudinal component exhibits an M-dependent oscillatory behavior that peaks near orthogonal incidence, while the generated transverse component reaches its maximum close to parallel propagation. The phase distributions show a clear topological imprint, including a reduction of the longitudinal-field phase winding to $$(M-1)$$ due to anisotropy-driven coupling. These observations shed light on the coupled roles of anisotropy, propagation angle, and vortex charge in shaping the vectorial structure of light inside uniaxial crystals. The results hold relevance for applications in optical manipulation, vector-beam generation, and quantum and classical information processing.",
            "content": "Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original... [625 chars]",
            "url": "https://www.nature.com/articles/s41598-025-32473-1?error=cookies_not_supported&code=4f23dd48-960d-428e-969e-dedc24f9b1ba",
            "image": "https://www.nature.com/static/images/favicons/nature/favicon-48x48-b52890008c.png",
            "publishedAt": "2026-01-24T14:01:47Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "2d11e8d109d56de9b77e31d6efaf44db",
            "title": "Development of capsaicin-derived prohibitin ligands to modulate the Aurora kinase A/PHB2 interaction and mitophagy in cancer cells",
            "description": "Aurora kinase A/AURKA is a serine/threonine kinase frequently overexpressed in cancer. Recent discoveries pointed to subcellular pools of AURKA, including at mitochondria. There, AURKA induces organelle clearance by mitophagy together with the autophagy mediator LC3, and its receptor PHB2. Here, we show that the natural product capsaicin modifies the AURKA/PHB2 interaction. We synthesize 16 capsaicin analogs, and Förster’s Resonance Energy Transfer/Fluorescence Lifetime Imaging Microscopy (FRET/FLIM) in breast cancer cells reveals that compounds 12 and 13 increase the AURKA/PHB2 interaction. Molecular docking shows that they bind to the inhibitory pocket of PHB2 and to the AURKA active site. We demonstrate that compound 13 specifically inhibits mitophagy while leaving AURKA activation unaltered at centrosomes. Our results demonstrate that compound 13 is a PHB ligand acting on the AURKA/PHB2 interaction. Thanks to its specificity, it may lead to the development of anticancer drugs targeting the mitochondrial functions of AURKA. Screening of 16 capsaicin chemical derivatives leads to the discovery of HMBB, the first mitochondrial inhibitor of the cell cycle protein AURKA in cellular models of breast cancer",
            "content": "Wang, T., Ma, F. & Qian, H. Defueling the cancer: ATP synthase as an emerging target in cancer therapy. Mol. Ther. Oncol. 23, 82–95 (2021).\nPickrell, A. M. & Youle, R. J. The roles of PINK1, parkin and mitochondrial fidelity in Parkinson’s disease. N... [7739 chars]",
            "url": "https://www.nature.com/articles/s42003-026-09573-3?error=cookies_not_supported&code=6875c6dd-ae0b-4a5c-8754-48efbe11f242",
            "image": "https://www.nature.com/static/images/favicons/nature/favicon-48x48-b52890008c.png",
            "publishedAt": "2026-01-24T13:55:06Z",
            "lang": "en",
            "source": {
                "id": "7abf0df285fbe93cdccffcc7c4088737",
                "name": "Nature",
                "url": "https://www.nature.com"
            }
        },
        {
            "id": "1e653cfb0b2337965653e2ed2ad2429e",
            "title": "January's full Wolf Moon leaps past the Eiffel Tower in stunning photo of Paris skyline",
            "description": "Photographer Martin Giraud captured a gorgeous composite view of the January full moon as it took to the evening sky on Jan. 3 to photobomb the Eiffel Tower in Paris.",
            "content": "Photographer Martin Giraud captured a breathtaking view of January's full \"Wolf Moon\" rising over the Paris skyline on the evening of Jan. 3 as it passed behind the iconic iron silhouette of the Eiffel Tower and the dome of the Sacré-Cœur Basilica.\nG... [1900 chars]",
            "url": "https://www.space.com/stargazing/astrophotography/januarys-full-wolf-moon-leaps-past-the-eiffel-tower-in-stunning-photo-of-paris-skyline",
            "image": "https://cdn.mos.cms.futurecdn.net/bgdZXssyad7EdXwEmTFQac-1266-80.jpg",
            "publishedAt": "2026-01-24T13:00:00Z",
            "lang": "en",
            "source": {
                "id": "024dd4370bda9e6e6791231c2a935d20",
                "name": "Space",
                "url": "https://www.space.com"
            }
        }
    ]
}